Mucosal chemokine adjuvant enhances synDNA vaccine-mediated responses to SARS-CoV-2 and provides heterologous protection in vivo점막 케모카인 보조제는 SARS-CoV-2에 대한 synDNA 백신 매개 반응을 향상시키고 생체 내 이종 보호를 제공합니다Article Published on 2022-07-192022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant approach CCL27 CD8 cell-mediated response Cell-mediated responses chemokine claimed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta VOC DNA DNA plasmid DNA vaccine Efficacy ENhance Frequency Heterologous heterologous challenge humoral IFNγ immunogenicity immunological in vivo interferon gamma mucosa mucosal mucosal surface mucosal surfaces mucosal. pandemic Plasmid Protective provide respiratory respiratory mucosa response SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines significant effect Spike protein Spike-specific antibody T cell T cells unique Vaccine vaccine efficacy variants of concern Viral viral control VOCs wild-type [DOI] 10.1016/j.xcrm.2022.100693 PMC 바로가기 [Article Type] Article
Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge마우스-적응 된 SARS-COV-2는 치명적인 SARS-COV 도전으로부터 동물을 보호한다Research Article Published on 2021-11-042022-08-13 Journal: PLoS Biology [Category] Biochemistry, MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome coronavirus antigenicity CMA3p20 coronavirus coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID-19 Critical cross-protection disease Economy element generate Heterologous heterologous challenge highlight human airway cell human airway cells human infection human SARS-CoV-2 strains Immune cell infiltration Immunity impair in vivo incorporation lack lung maintain mechanism Mouse models mouse-adapted SARS-CoV-2 mouse-adapted SARS-CoV-2 strains mouse-adapted strain mouse-adapted strain of SARS-CoV-2 Mutation natural infection offer overcome pandemic PROTECT public health Replication Research respiratory reverse genetic system robust SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2–infected mice severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Strains Vaccine variants variants of concern Viral viral replication [DOI] 10.1371/journal.pbio.3001284 PMC 바로가기 [Article Type] Research Article
577. COVI-VAC™, a Live Attenuated COVID-19 Vaccine, Provides Single Dose Protection Against Heterologous Challenge with SARS-CoV-2 Beta (B.1.351) in the Syrian Golden Hamster ModelPoster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] affected Against age Amino acid analysis Analysis animal B.1.351 Beta biodistribution board challenge change clinical trials conducted COVID-19 COVID-19 vaccine demonstrated Efficacy employee evaluated figure furin cleavage site hamster Heterologous heterologous challenge Histopathology in vivo Inc include intranasal intranasally key tissue Kushnir less maintain member Model Mutation neutralization neutralizing antibody non-human primate model Phase 1 PhD presenting prevented protection Protective qPCR raise reduced Result Robert SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant sequence serum Seven silent single dose spike-based vaccines Syrian Golden hamsters timepoint Vaccine variant variant of SARS-CoV-2 Viral antigen viral antigens viral evolution viral replication weighed weight weight loss wildtype [DOI] 10.1093/ofid/ofab466.775 PMC 바로가기 [Article Type] Poster Abstracts
Development of a Broadly Accessible Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine PlatformVaccines and Antiviral Agents Published on 2018-03-142022-10-30 Journal: Journal of Virology [Category] Coronavirus, Fulltext, MERS, SARS, 조류인플루엔자, [키워드] addition Affect Aged antigen expression approach approaches biosafety BSL2 candidate vaccine condition coronavirus coronavirus development disease effective Efficacy Epidemics Heterologous heterologous challenge human populations in vivo Laboratory majority mice microbial model systems norovirus Norovirus outbreak outcome Particle Pathogens platform provide public health recombinant proteins replicon reported reservoir robust Safe Taking utility vaccination Vaccine vaccine platform vaccine strain VEE replicon Venezuelan equine encephalitis virus virus virus-like particles viruses VRP while wild-type [DOI] 10.1128/JVI.00027-18 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
Inter-Clade Protection Offered by Mw-Adjuvanted Recombinant HA, NP Proteins, and M2e Peptide Combination Vaccine in Mice Correlates with Cellular Immune ResponseOriginal Research Published on 2017-01-092023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] adjuvant H5N1 heterologous challenge Immunophenotyping M2e Mw protection Vaccine [DOI] 10.3389/fimmu.2016.00674 PMC 바로가기 [Article Type] Original Research
Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike VariantsResearch Article Published on 2006-12-262022-10-29 Journal: PLoS Medicine [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] 2003 acute respiratory syndrome addition Administered Antisera bat bats Bearing candidate vaccine caused Cell cellular immune responses center characterized chimeric China Cluster coding Complete Consequences Control coronavirus cross death death rate death rates develop died different disease effective Efficacy eight elicit Epidemic etiological agent examined expressing finding flu found future infection Gene genetic material genetics glycoprotein group Guidance Heterologous heterologous challenge homologous homologous or heterologous homologous strain challenge Human human airway epithelial humans identify immune response immunized immunopathology infect Infected Infection information injected lung mice much higher neutralization nucleocapsid Older Outbreaks Particle pathological change pathology peaked phylogenetic analyses populations PROTECT Protein Proteins provide provided recombinant related virus related viruses replicated researcher reservoirs resource robust rodents S glycoprotein SARS Coronavirus SARS infection SARS virus SARS-CoV SARS-CoV N SARS-CoV S SARS-CoV S protein SARS-CoV vaccine SARS-CoV virus senescent severe severe pneumonia spike spike glycoprotein Spread strain Strains tested the disease the vaccine thought vaccination Vaccine vaccine candidate Vaccine design Vaccine development Vaccines variant Venezuelan equine encephalitis virus virus virus strain was used Web West Nile Virus World Health Organization zoonosis zoonotic [DOI] 10.1371/journal.pmed.0030525 PMC 바로가기 [Article Type] Research Article